Nanjing Chengshi Biomedical Technology Co., Ltd. is involved in three interconnected and complementary key areas in mRNA vaccine development: antigen selection, expression architecture, and vaccine architecture. The company possesses a mature R&D, testing, and production system that supports in-depth exploration and innovation in these areas.
1、Antigen Selection and Design
- Antigen selection is a crucial initial step in vaccine development, involving the precise screening of targets from different pathogens. Chengshi's professional team utilizes reverse vaccinology technology to effectively select the most immunogenic target sequences, addressing the challenge of antigen selection in vaccine development. By deeply analyzing antigen sequences and designing reasonable sequence combinations, we have achieved precise selection of key sequences and the development of multi-target vaccines, enhancing the preventive and therapeutic effects of vaccines.
2. Antigen Expression Architecture Design
- In mRNA vaccine development, ensuring the efficient expression of antigen sequences is crucial. Our R&D team innovatively developed an antigen expression architecture that efficiently induces humoral and cellular immune responses and continues to explore new expression systems to further the research and production of nucleic acid vaccines.。
3. mRNA Vaccine Architecture Design
- The architecture of mRNA vaccines is diverse, including capped RNA, uncapped RNA, self-replicating RNA, and circRNA, among others. However, there are universal differences in various vaccine architectures. Through extensive experimentation, our team has made original breakthroughs in vaccine architecture design, successfully applying uncapped RNA and self-replicating RNA architectures to multiple vaccine projects, laying a solid data foundation for future optimization and innovation.
4,Patent Certificate
PDF: An mRNA vaccine for broad-spectrum antiviral diarrhea in bovines and its application.
PDF: A nucleic acid vaccine for Duck Tembusu virus and its application.
